Monterey Bay Aquarium Research Institute

Lars Tomanek, Ph.D.

Cal Poly San Luis Obispo, Environmental Proteomics Laboratory

The Proteomic Response of Marine Organisms to Oxidative,
Heat, and Osmotic Stress

Lars Tomanek

Wednesday - July 15, 2009

Pacific Forum – 3:00 p.m.

Marine animals are exposed to a wide variety of stresses. Intertidal organisms experience heat stress during low tides, estuarine organisms are exposed to high levels of pollutants and often experience great fluctuations in salinity. Proteins play an important role in how marine animals cope with a stressful environment. However, marine organisms that are of interest to the ecologist are often not accessible to a biochemical analysis. We have developed a methodology that opens organisms with limited sequence coverage to the analysis of their proteome, the complement of hundreds to thousands of their proteins. Characterizing expression levels of so many proteins provides a global perspective and provides a systems perspective that probably reflects the dynamic changes more realistically than alternative conventional approaches.


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